Depression and Suicide: Background and Statistics

We, the Depressed, in our darkest hours have
No energy to move
No reason to live
No will to survive
No hope in a cure
No reason to try.
We roam the earth as the living dead
Wanting only to extinguish
That persistent heart that beats,
That ceaseless breath that enters,
That pain that never relents.
 
Every cell of our being wants to die,
Yet Do We Live.






Background
Throughout the world, about 2000 people kill themselves each day. That's about 80 per hour, three quarters of a million a year. In the U.S., there are more than 80 deaths from suicide every day, 30,000 every year. This is the equivalent of a fully loaded jumbo jet crash every fifth day. From another perspective, you are more likely to kill yourself than be killed by someone else.



Another estimated 300,000 (or more) Americans a year survive a suicide attempt. A majority have injuries minor enough to need no more than emergency room treatment. However, about 116,000 are hospitalized, of whom 110,000 are eventually discharged alive. Their average hospital stay is 10 days; the average cost is $15,000.



"...without knowledge of proper dosages and methods, suicide attempts are often bungled, leaving the victim worse off than before. Many intended suicides by gunshot leave the person alive but brain-damaged; drug overdoses that are not fatal may have the same effect. One eighty-three-year-old woman obtained an insufficient number of pills and lost consciousness but did not die; her daughter ended up smothering her with a plastic bag."



Seventeen percent, some 19,000, of these people are permanently disabled, restricted in their ability to work, each year, at a cost of $127,000 per person. Such injury is tragic, either if someone were trying to kill herself and failed, or, perhaps even sadder, if the suicide attempt was intended as a "cry for help".



About 1.4% of Americans end their lives by suicide. This is the eighth leading cause of death in the U.S., and ranks fourth in years of lost life. The largest increase in the last 30 years has been among people between 15-24 years old, but the highest rates are still among the elderly. Men kill themselves at about four times the rate for women (19.8/100,000 vs 4.5/100,000 in 1994). Around 3% of adults make one or more suicide attempts.



There are more suicides than the official numbers show, but there is no general agreement as to how many more. Estimates of under-reporting range from around 1% to 300%...



Reasons for under-reporting include:
(1) Families or family physicians may hide evidence due to the stigma of suicide. For example, "Physicians and surviving relatives have told me in confidence of many deaths which were suicides, but which had been certified as natural or accidental deaths by a physician, either through error, misinformation, or deliberate falsehood....My own estimate is that there were an additional 10,000 deaths yearly [in the U.S.] which would have been certified as suicides if there had been complete and impartial investigations."
(2) The determination of cause-of-death is judged by local standards, which vary widely. In one egregious instance, a coroner would cite suicide only in deaths where a suicide note was found, and suicide notes are only found in around one quarter of known suicides.
(3) There are lots of ambiguous situations, some of which are suicides, but which almost always end up classified as "accidental" or "undetermined" the single-car "accident" with no skid marks; the "fall" off the night ferry; the "stumble" in front of the train; the "inadvertent" overdose; the gun-cleaning "mishap".
(4) Compared to the "accidental" or "undetermined" motive categories, there is a much larger number of deaths officially classified as "ill-defined and unknown causes of mortality," where even the actual cause of death is uncertain, and some of which are undoubtedly suicides.
(5) The frequency of physician-assisted suicide for the terminally ill is unknown, but, based on anecdotal evidence, is probably both substantial and increasing.



On the other side of the ledger, some doubtful cases may be classified as suicides as well. These usually occur in institutions, such as prisons, hospitals, religious orders, and the military, which control their population more-or-less completely.



For such institutions a verdict of suicide is likely to be the least embarrassing (after "natural") cause of death: homicides must be investigated and a murderer sought; accidents may be the basis of negligence lawsuits.
The number of suicide attempts is also subject to dispute. Based on a range of studies, there are probably between 10-20 attempts for every suicide, or roughly 300,000-600,000 attempts per year in the U.S. Yet more than half of suiciders kill themselves on their first try.









Race
Suicide rates among American Indian and Alaskan natives between 15 and 34 years are almost twice the national average for this age range. Hispanic females make significantly more suicide attempts than their male or non-Hispanic counterparts.



The risk of suicide is increased by concurrent alcohol and drug abuse, access to lethal means, hopelessness, pessimism, and impulsivity, and is reduced by help-seeking behavior, access to psychiatric treatment, and availability of family and other social supports.



Sex
More women than men seek treatment for depression, but this is not necessarily reflective of the true incidence of the disease.
  • Although depression is more often diagnosed in women, more men than women die from suicide by a factor of 4.5:1. White men complete more than 78% of all suicides, and 56% of suicide deaths in males involve firearms. Poisoning is the predominant method among females.

  • An estimated 8-25 attempted suicides occur for every completion. Many of these are never discovered or never reported. It is important to understand that the majority of suicide attempts are expressions of extreme distress, not merely bids for attention.

Age
The highest suicide rates are found in men older than 75 years. However, suicide is also a selective killer of youth. It is the third leading cause of death among people aged 15-24 years, after unintentional injuries and homicide, and the second leading cause of death in college students. The mean age for successful completed suicides is 40 years.



For adolescents, the attempt-to-fatality ratio may be 50:1; but this average masks the fact that the death rate for boys is a hundred times higher than for girls: around 10 percent and 0.1 percent, respectively. About 11% of high school students have made at least one suicide attempt. Ninety percent of adolescents' suicide attempts occur at home, and parents are home 70% of the time.



Risk Factors
Risk factors for thoughts of suicide can vary with age, gender, and ethnic group. And risk factors often occur in combinations.



Over 90% of people who die by suicide have clinical depression or another diagnosable mental disorder. Many times, people who die by suicide have a substance abuse problem. Often they have that problem in combination with other mental disorders.



Adverse or traumatic life events in combination with other risk factors, such as clinical depression, may lead to suicide. But suicide and suicidal behavior are never normal responses to stress.



Other risk factors for suicide include:
  • One or more prior suicide attempts.

  • Family history of mental disorder or substance abuse.

  • Family history of suicide.

  • Family violence.

  • Physical or sexual abuse.

  • Keeping firearms in the home.

  • Incarceration.

  • Exposure to the suicidal behavior of others.





Sources and Additional Information:

Nutrition Causing Depression and Sleeplessness

When you consume too little fat, cholesterol or sugars, your body ‘punishes’ you with depressions and / or sleeplessness, through receptors in the brain, to force you to consume more of these essential nutrients. Elevated blood-protein levels impair neurotransmitter metabolism regulating sleep and feelings of happiness. Beta-carbolines from prepared food (proteinacous prepared food in particular), opioid peptides from wheat- and dairy products and cadmium from vegetables and grains do exactly the same.



To be happy and sleep well: Consume as little (especially at night) prepared food, vegetables, grains, milk and wheat-products. Wake up when the sun rises, and eat as much fruits as you want and sufficient fresh raw egg yolk (mixed with avocado) or fresh raw salmon. Great 'happy fruits' are: dried date, fig, papaya, banana, strawberries, sweet cherries, orange, mango, pineapple, grapefruit and hazelnuts, all for optimizing serotonine production.


Why Certain Food can Cause Depression?








Cholesterol
Being happy is much more than just a feeling. Feelings of happiness / depressions tell you whether your diet is okay. And if you don’t sleep well, again you have to take a look at your diet first. For example, cholesterol is an essential nutrient; 10 to 20% of the brain is composed of cholesterol, and vitamin D and the sex hormones are also composed of cholesterol. That's why the body needs sufficient cholesterol all the time. And to make sure you consume sufficient 'clean' cholesterol, your body warns you if you don't; through causing depressions and mood-swings. A number of scientific investigations have proved that in people trying to commit suicide, cholesterol-level is lower.



Cholesterol-products like progesterone, estradiol and testosterone increase serotonine-receptor activity. Low cholesterol level decreases serotonine-receptor activity.



And feeling happy is partly regulated through serotonine-receptors in the brain. Serotonine is a neurotransmitter not just regulating feelings of happiness, but also the ability to fall asleep, and partly influences cognitive abilities, pain, fear and appetite.  







Fibers in wheat potato, maize, oat, rice, pea and soybean inhibit cholesterol absorption, what can make you depressed and sleepless. Logically, bad-functioning ovaries (producing progesterone and estradiol) can also cause depressions.



To make sure you absorb sufficient cholesterol, consume some fresh raw egg yolk every day (mixed with avocado for example); it will make you sleep like a baby. Be sure the eggs are fresh and obtained from hens fed natural foods only (like raw grains and grass).
You can also consume sashimi (fresh raw fish).
  
Sugars
Sugar consumption is as essential as cholesterol is; sugars are the main source of energy for the brain and muscles; dietary sugars (sucrose, starch, and even most fructose) are mainly transformed into glucose. To assure sufficient sugars are consumed, glucose is essential in composing serotonine, ‘the happy-maker’.



Serotonine is composed of tryptophan, an amino acid (protein commonly is composed of 18 different amino acids). When blood-glucose level is low, muscles and organs do not absorb amino acids from the blood for maintenance. And among all those other amino acids, it is much harder for the brain to pick up tryptophan. Glucose stimulates amino acid absorption by the muscles and organs, and therefore tryptophan absorption by the brain. The sweet taste of sugar and honey is the promise of happiness.

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Fat
Fat is as essential as cholesterol and sugars are. Fats are the main source of energy for the heart and the colon. To assure sufficient fat is consumed, a particular fatty acid, oleamide, is required to activate serotonine receptors. Making oleamide, and therefore fat, essential to fall a sleep. If you wake up in the middle of the night for no reason, you mat try to consume something both fat and sweet, like raisins with butter. It will probably make you sleep like a baby.



Too Much Protein
But yes, being grumpy, you first need to make sure your diet contains sufficient clean cholesterol, fat and sugars. However, consuming too little essential nutrients is not the only cause. Consuming too much proteinous food in general, can also cause depressions and sleeplessness. Here are the reasons why;
-    To transform tryptophan into serotonine, vitamin B6 is required. Consuming more protein than you need, requires extra vitamin B6 (and B2 and folic acid). Consuming too much proteinous food inhibits serotonine production.
-    Consuming too much increases blood-amino acid levels, making it harder for the rain to specifically pick up tryptophan. The amino acid phenylalanine inhibits serotonine production, through inhibiting decarboxylation of 5-hydroxy-L-tryptophane into serotonine.



-    Consuming too much protein increases blood-phenylalanine level. The amino acid phenylalanine inhibits serotonine production, through inhibiting decarboxylation of 5-hydroxy-L-tryptophane into serotonine.



-    Consuming too much protein increases blood-leucine level. The amino acid leucine enhances tryptophan-pyrrolase, irreversibly decomposing tryptophan. Unfortunately, the liver cannot decompose leucine, tissues like muscles can.



-    Prepared food contains lots of beta-carbolines inhibiting tryptophan transport by albumin. Free tryptophan not transported by albumin does not reach the brain, and is decomposed. Especially consuming prepared proteinous food can make you depressed and sleepless.



-    Besides methionine (another amino acid), tryptophan is easily damaged by heat. Every time food is re-heated, tryptophan gets lost. 



-    Beta-carbolines from prepared food can occupy serotonine receptors, because many beta-carbolines are composed of tryptophan (or its amines: serotonine and tryptamine); the basic properties are equal.



-    Beta-carbolines from prepared food can directly disturb sleep through blocking benzodiazepine receptors.



-   Beta-carbolines from prepared food can also disturb sleep by causing stress through the noradrenergic system.



Consume as much fruit, and sashimi or fresh raw egg yolk (gently stirred through a fruit shake for example), instead of prepared food. And especially do not consume prepared food at night, to prevent prolonged digestion to impair sleep.
  

Too Much Vegetables and Grains
Consuming vegetables and grains can also make you depressed and sleepless. Even a low intake of cadmium decreases serotonine level. Grains and vegetables in particular can contain high levels of cadmium (from phosphate fertilizers). That's why 'health freaks' consuming lots of vegetables and grains very often are not exactly 'shiny happy people'. What we nowadays consider a normal intake of cadmium, is already 50% of maximally admitted amounts. You're not a cow, nor a pigeon; you don't need any grains or vegetables at all. Fruits and some animal foods combined contain all the nutrients you need.



Too Much Wheat and Dairy Products
Consuming wheat and dairy products can also make you sleepless and depressed. Endorphins are opioid peptides made by the body. The anesthetic effects of endorphins are required to make you fall asleep. Damaged (due to heat) wheat- and milk-opioid peptides can occupy and destroy endorphin receptors in the brain. Therefore endorphins cannot bind to their receptors, what impairs falling asleep.



Endorphin- and serotonine-metabolism are closely related, and opioid peptides can directly inhibit serotonine release. Therefore, besides sleeplessness, opioid peptides can also cause depressions. In chronically depressed people, free endorphin level is 3 fold higher (because part of endorphin receptors have been destroyed).



Long-Term Use of Hormonal Contraceptive
Long-term hormonal contraceptive use can make you depressed and sleepless too. Hormonal contraceptives act through dominating production and secretion of hormones by the body. It is very possible that after menopause adrenal gland estrogen production does not recover from being diminished through long-term contraceptive use. While estrogen (and other hormones) enhances serotonine-receptor activity.



Oral contraceptive use increases cortisol level, increasing transformation of tryptophan into xanthurenic acid, kynurenine and hydroxykynurenine. Therefore less tryptophan can be transformed into serotonine.



Antibiotics
Use of antibiotics can cause sleeplessness too. Bacteria in the colon produces factor S, inducing long-wave sleep pattern. Antibiotics kill both bacteria causing diseases and bacteria producing factor S. Antibiotics should only be used in an emergency situation.



Too Little Vitamin B3
Too little vitamin B3 enhances serotonine deficiency. Vitamin B3 deficiency usually comes with serotonine deficiency, for both substances are composed of tryptophan. If sufficient B3 is available, no tryptophan needs to be transformed into B3, leaving more tryptophan to be transformed into serotonine. Like meat and nuts, raw salmon, -tuna and -mackerel are loaded with B3. ‘Happy-‘and ‘sleepy foods’ improve both serotonine- and vitamin B3 production.



'Happy-' and 'Sleepy-food'


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The body actually doesn’t need much tryptophan to compose serotonine. And yet you can consume lots of protein containing lots of tryptophan, with serotonine production remaining far too low. Simply because protein also contains amino acids inhibiting serotonine production, like leucine and phenylalanine in particular. Optimizing serotonine metabolism therefore is not about consuming protein high in tryptophan, but about consuming protein containing relatively more tryptophan than leucine and phenylalanine. Consuming such proteins improves serotonine metabolism, allowing you to feel happy, and sleep well.



Great 'happy-‘ and 'sleepy-foods’ are fruits like dried dates, figs, papaya, banana, strawberries, sweet cherries, orange, mango, pineapple, grapefruit and hazelnuts, combined with fresh raw egg yolk (because of the cholesterol), alternated with fresh raw salmon (because of the vitamin B3).



Of course the best 'happy-foods' are easy to digest and should be consumed raw.



Mushrooms and potato crisps are best ‘happy’-munch-food (crisps combine well with egg yolk and avocado), but consuming mushrooms can cause cramps.



To know what foods can improve your sleep and happiness, you have to look at their SPF. ‘SPF’ = ‘Serotonine-Production Factor’ = tryptophan / (phenylalanine + leucine).



For example: if the SPF of a certain food-protein is 50%, this protein contains exactly as much tryptophan as the average of phenylalanine and leucine, strongly improving serotonine production. All foods with a SPF below 10%, more or less inhibit serotonine production. Whether these low-SPF foods actually do inhibit serotonine production, depends on how much protein they contain.



To enhance serotonine production, you should consume as little low-SPF foods, especially when high in protein. So, consuming corn flakes for breakfast, bread for lunch, and pasta with lobster or horsemeat for dinner, is an extremely bad idea.
                                     SPF*                Food
                                     95%                  edible boletus
                                     48%                  hemp seed, commercial
                                     43%                  date, dried
                                     32%                  papaya
                                     32%                  chanterelle
                                     29%                  banana
                                     22%                  strawberries
                                     21%                  sweet cherries
                                     17%                  mango
                                     17%                  cashew nut
                                     16%                  pineapple
                                     16%                  grapefruit
                                     15%                  fig, dried
                                     14%                  hazelnut
                                     14%                  carrots
                                     13%                  potato crisps
                                     13%                  orange
                                     12%                  guava
                                     12%                  mushroom
                                     12%                  crawfish
                                     12%                  egg yolk
                                     12%                  apricot
                                     11%                  oyster mushroom
                                     11%                  wheat whole meal bread
                                     11%                  peach
                                     11%                  tomato
                                     11%                  oriental sesame              
                                     10%                  sunflower seed
                                     10%                  chicken breast
                                     10%                  salmon
                                     10%                  mackerel
                                     10%                  beef, muscles only
                                     10%                  goose
                                     10%                  rolled oats
                                     10%                  green peas, canned
                                     10%                  Brazil nut
                                       9%                  walnut
                                       9%                  peanut
                                       9%                  tuna
                                       9%                  turkey, young
                                       9%                  Soya bean
                                       9%                  crisp bread
                                       9%                  mandarins
                                       9%                  cow’s milk
                                       8%                  apple
                                       8%                  lamb, muscles only
                                       8%                  rice
                                       8%                  white bread
                                       8%                  coconut
                                       8%                  Lamb’s lettuce
                                       8%                  quark, fresh cheese
                                       7%                  lentil
                                       7%                  avocado
                                       7%                  cheddar cheese
                                       7%                  yogurt
                                       6%                  almond
                                       6%                  bread rolls
                                       6%                  oyster
                                       6%                  white beans
                                       6%                  rye bread
                                       5%                  horsemeat
                                       5%                  pasta made with eggs
                                       5%                  lobster
                                       4%                  shredded wheat bread
                                       3%                  sweet corn
                                       3%                  corn flakes
 

Warning: Besides tryptophan, ‘happy foods’ like papaya, banana and pineapple also contain lots of serotonine, which you cannot utilize as serotonine in the brain. If you are not used to eating much of theses fruits, your body needs time to produce more enzymes decomposing the serotonine from these fruits. So, if you are not used to eating much of these fruits, increase consumption gradually to enable enzyme production keeping up with serotonine consumption. If you don’t, exogenous serotonine is not decomposed sufficiently, and can harden heart-muscles, causing mild heart pains.



General List of Foods that are Known to Cause Depression 
  • Almond

  • Apple

  • Avocado

  • Beef, Muscles Only

  • Brazil Nut

  • Bread Rolls

  • Cheddar Cheese

  • Chicken Breast

  • Coconut

  • Corn Flakes

  • Cow’s Milk

  • Crisp Bread

  • Goose

  • Green Peas, Canned

  • Horsemeat

  • Lamb, Muscles Only

  • Lamb’s Lettuce

  • Lentil

  • Lobster

  • Mackerel

  • Mandarins

  • Oyster

  • Pasta, made with Eggs

  • Peanut

  • Quark, Fresh Cheese

  • Rice

  • Rolled Oats

  • Rye Bread

  • Salmon

  • Shredded Wheat Bread

  • Soya Bean

  • Sunflower Seed

  • Sweet Corn

  • Tuna

  • Turkey, Young

  • Walnut

  • White Beans

  • White Bread

  • Yogurt

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Sources and Additional Information:

Major depression with psychotic features



Psychotic major depression (PMD) is a type of depression that can include symptoms and treatments that are different from those of non-psychotic major depressive disorder (NPMD). PMD is estimated to affect about 0.4% of the population (or one in every 250 people). Note that roughly 25 percent of people who are admitted to the hospital for depression suffer from what's called psychotic depression.



Psychotic depression is characterized by not only depressive symptoms, but also by hallucinations (seeing or hearing things that aren’t really there) or delusions (irrational thoughts and fears). Often psychotically depressed people become paranoid or come to believe that their thoughts are not their own (thought insertion) or that others can ‘hear’ their thoughts (thought broadcasting).









Symptoms
Currently, PMD is considered a severe form of major depression, but patients with mild or moderate depression may still have psychotic features. Many people with PMD experience delusions, which are beliefs or feelings that are untrue or unsupported.



Paranoid delusions or delusions of guilt may be the most common psychotic symptoms in PMD. Patients with PMD often have concerns that people are paying special attention to them or are trying to persecute them. Patients who experience delusional guilt may believe that they are being punished for past misdeeds or are responsible for problems they couldn’t possibly be responsible for.



Other common delusions include those in which people are concerned that something is terribly wrong with their bodies and physical health, when actually there isn’t anything wrong. Unlike other psychotic disorders, the delusions in PMD may not be very obvious. Delusions appear to be more common than hallucinations in PMD, but some people with PMD do hallucinate, or see or hear things that others do not. Auditory hallucinations (sounds) are perhaps the most common hallucinations seen in PMD. While other patients may report seeing, touching or smelling things that are not there, it is less common.



Other symptoms that are common in PMD are agitation, difficulty falling asleep, and frequent waking during the night. In addition, patients with PMD may have a greater suicide risk than patients with NPMD. Finally, those with PMD may have greater cognitive deficits (e.g., memory problems) than those with NPMD.



Diagnostic criteria
According to the Diagnostic and Statistical Manual of Mental Disorders (DSM), a widely used manual for diagnosing mental disorders, patients who show at least six of the following symptoms in a period of two weeks may be diagnosed with PMD. In order to qualify for a PMD diagnosis, patients need to report either (1) or (2), and (10), along with three or four other symptoms (for a total of six). These symptoms also must be different from how patients felt or behaved at a previous time.
  1. Depressed mood most of the day nearly every day.

  2. Loss of interest or pleasure in all, or almost all, activities most of the day nearly every day.

  3. Significant weight loss or weight gain, OR decrease or increase in appetite nearly every day.

  4. Insomnia OR hypersomnia (sleeping excessively) nearly everyday.

  5. Psychomotor agitation (moving more quickly) OR retardation(moving more slowly) nearly every day, so much that other people notice.

  6. Fatigue OR loss of energy nearly every day.

  7. Feelings of worthlessness OR excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick).

  8. Diminished ability to think or concentrate, OR indecisiveness, nearly every day.

  9. Recurrent thoughts of death (not just fear of dying), recurrent ideas about suicide without a specific plan, or a suicide attempt or specific plan for committing. suicide

  10. Presence of psychosis (hallucinations/delusions).









Causes of Psychotic Depression
As is the case with other forms of depression, the exact causes of psychotic depression are not known. Research does however suggest that hereditary factors and a history of other depressive conditions such as bipolar disorder often play a role in susceptibility. In addition, abnormal levels of hormones in the bloodstream may also aggravate the onset of psychotic depression.



Psychotic depression is frequently associated with high levels of a hormone called 'cortisol' in the blood. (Cortisol is a hormone produced by the adrenal cortex. High levels of cortisol have been associated with stress.)



Treatment of Psychotic Depression
Treatment for psychotic depression requires a longer hospital stay and close follow-up by a mental health professional. Combinations of tricyclic antidepressants and antipsychotic medications have been most effective in easing symptoms. The addition of lithium to this combination can be beneficial for those with bipolar disorder. Electroconvulsive therapy is very effective for this condition, but it is generally a second line treatment.



Researchers are also studying the effectiveness of RU-486 (the “abortion pill” and “emergency contraceptive”), which is said to dramatically relieve psychotic depression.



Prognosis of Psychotic Depression
Treatment is very effective for psychotic depression and people are able to recover, usually within a year, but continual medical follow-up may be necessary. Generally, the depressive symptoms have a much higher rate of recurrence than the psychotic symptoms. It is important, however, that a person experiencing these symptoms be properly diagnosed because treatment is different than for other major depressive illnesses and risk of suicide is greater.





Sources and Additional Information:

Causes and Symptoms of Atypical Depression

Atypical depression is actually the most common subtype of depression in outpatients, according to Andrew Nierenberg MD, Associate Director of the Depression and Clinical Research Program at Massachusetts General Hospital, affecting anywhere from 25 to 42 percent of the depressed population.



According to the DSM-IV, as opposed to major depression, the patient with atypical features experiences mood reactivity, with improved mood when something good happens. In addition, the DSM-IV mandates at least two of the following: increase in appetite or weight gain (as opposed to the reduced appetite or weight loss of "typical" depression); excessive sleeping (as opposed to insomnia); leaden paralysis; and sensitivity to rejection.



A study by Agosti and Stewart published in the Journal of Affective Disorders in 2001 found that patients with atypical depression experienced greater functional impairment than their non-atypical counterparts, as well as exhibiting more interpersonal sensitivity, more chronic dysphoria, and more bipolar II disorder. Women comprised 70 percent of the study population of those with atypical depression.

A study by Posternak and Zimmerman published in Psychiatry Research in 2001 cast doubt on the only feature of atypical depression that is mandatory under the DSM - that of mood reactivity. In their study, the authors evaluated the five symptoms of atypical depression across five different groups of patients (including women, different age groups, and according to severity and length of time of symptoms), and discovered mood reactivity only featured among the women patients, suggesting this particular criteria should be dropped.


The same study also found at best a limited association between the five atypical features among the five clinical profiles. Women, for instance, consistently displayed four of the five symptoms for atypical depression while patients under age 30 exhibited only one. Two patients, then, may have two different sets of symptoms, which suggests there is nothing typical about atypical depression.





A multi-center study identified a group with atypical depression, representing 36.4 percent of the depressed sample in the US National Comorbidity Survey. The study found that those with atypical depression were mostly women, had higher rates of depressive symptoms, more co-occurring psychiatric illnesses, more suicidal thoughts and attempts, greater disability and restricted activity days, more use of some healthcare services, greater paternal depression, and more childhood neglect and sexual abuse.


Atypical depression is not new. Indeed, it is one of the most common kinds of depression. The name atypical depression comes from the fact many of its symptoms are opposite to those of some severe depressions. If you have atypical depression, you may feel as though your body is so heavy you can’t lift your head or walk.



Experts have linked atypical depression to other psychiatric problems such as borderline personality disorder, but only a professional can diagnose you with having atypical depression. Atypical depression may occur together with panic disorder. Many people with atypical depression abuse drugs or alcohol.
People with atypical depression are externally validated. They feel good when people give them positive compliments and they feel bad when someone criticizes them. Their moods change and shift as quickly as the wind depending if they are isolated and lonely or with a group of friends enjoying a night out on the town.




Symptoms of atypical depression:
  • Sleeping more than 10 hours (hypersomnia).

  • Cyclical depressive mood.

  • Emotional sensitivity to criticism and rejection.

  • Leaden paralysis (i.e., heavy, leaden feelings in arms or legs).

  • Feelings of lethargy and emotional paralysis.

  • Increased appetite and food cravings for carbohydrates (comfort eating).

The exact reason of atypical depression is still unknown. Still doctors believe that genes and environment has something to do with this form of depression. Here are some of the possible causes of atypical depression:
  • High blood pressure and higher level of cholesterol.

  • Sleeping disturbances.

  • Stress; especially due to the loss of friends or loved ones, or those things that you love the most.

  • Family history of depression because of genetic factors.

  • Mental, physical or sexual abuse that happened in the past.

  • Intake of Alcohol or drugs; it is proved that more than 20% drug addicts suffer from depression.

  • Nutritional deficiencies.

  • Nutrition problems at childhood stage.

  • Too much or very little exposure to light is also a major factor that contributes to atypical depression.

  • Certain medications, including those for high blood pressure, high cholesterol, or irregular heartbeat.

Remember that if you have light forms of atypical depression, you are at higher risk for more serious and sudden major depression. You may not even know you have atypical depression because you feel depressed most of the time. You may try to hide your symptoms of atypical depression by working harder, going on diets, analyzing your failed relationships and staying on a rigid schedule; however, you have only covered up your atypical depression not cured it.



Sources and Additional Information:

Major Depression Symptoms

A person who suffers from a major depressive disorder (sometimes also referred to as clinical depression or major depression) must either have a depressed mood or a loss of interest or pleasure in daily activities consistently for at least a 2 week period. This mood must represent a change from the person's normal mood. Social, occupational, educational or other important functioning must also be negatively impaired by the change in mood. For instance, a person who has missed work or school because of their depression, or has stopped attending classes altogether, or attending usual social engagements.



A depressed mood caused by substances (such as drugs, alcohol, medications) is not considered a major depressive disorder, nor is one which is caused by a general medical condition. Major depressive disorder generally cannot be diagnosed if a person has a history of manic, hypomanic, or mixed episodes (e.g., a bipolar disorder) or if the depressed mood is better accounted for by schizoaffective disorder and is not superimposed on schizophrenia, a delusion or psychotic disorder. Typically the diagnosis of major depression is also not made if the person is grieving over a significant loss in their lives.









Depression varies from person to person, and it has special traits and specifics based on the age, gender, personality and other factors, but there are some common signs and symptoms to be observed.
Clinical depression is characterized by the presence of the majority of these symptoms:
  • Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feeling sad or empty) or observation made by others (e.g., appears tearful). (In children and adolescents, this may be characterized as an irritable mood.)

  • Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day. Loss of interest in activities or hobbies once pleasurable, including sex.

  • Significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day.

  • Either insomnia, especially waking in the early hours of the morning, or oversleeping (also known as hypersomnia).

  • Psychomotor agitation or retardation nearly every day. Either feeling “keyed up” and restless or sluggish and physically slowed down.

  • Fatigue or loss of energy nearly every day. Feeling fatigued and physically drained. Even small tasks are exhausting or take longer.

  • Feelings of worthlessness or excessive or inappropriate guilt nearly every day. Harsh criticism of perceived faults and mistakes.

  • Diminished ability to think or concentrate, or indecisiveness, nearly every day. Trouble focusing, making decisions, or remembering things.

  • Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

  • Persistent aches or pains, headaches, cramps or digestive problems that do not ease even with treatment.

In addition, for a diagnosis of major depression to be made, the symptoms must not be better accounted for by Bereavement, i.e., after the loss of a loved one, the symptoms persist for longer than 2 months or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation.



If you have 2 to 4 symptoms for a period of at least 2 years (1 year for a child), you may have a long-term form of depression called dysthymic disorder (dysthymia).



Many health professionals see people with general symptoms that may be difficult to link to depression. These symptoms, which commonly occur with depression, include:
  • Having digestive problems, including constipation or diarrhea.

  • Losing interest in sex or being unable to perform sexually.

  • Not moving or talking for hours.

  • Increased tearfulness, anger, and generally not feeling well, along with anxiety and tension.

  • Sometimes, a feeling of heaviness in the arms and legs.

  • Sensitivity to rejection.

  • Night Sweats and sudden awakening.









Sources and Additional Reading:

Stop-smoking drug Chantix might cause depression

The U.S. Food and Drug Administration (FDA) has issued a notice that it is conducting a safety review of the stop-smoking drug Chantix (varenicline) due to reports of suicidal thoughts and aggressive and erratic behavior in patients who were taking it.








In conducting its review, the FDA will be looking at postmarketing cases submitted by the drug's manufacturer, Pfizer, as well as reports in the press and on internet sites. Chantix (varenicline) is a medication used to quit smoking. Starting from November 2007, when the FDA began investigating reports of depression, agitation, and suicidal behavior among patients taking the medicine as much as 37 Chantix suicides and more than 400 reports of suicidal behavior that may have been linked to Chantix have been received by the end of the year. According to the FDA, a link between Chantix and serious psychiatric complications is becoming progressively probable. Additionally, the drug may worsen preexisting psychiatric illness or cause a recurrence of past issues. By May 2008, Chantix was linked to more than 3,000 reports of serious side effects. By November of the same year, data from the FDA’s Adverse Event Reporting System showed that more reported serious injuries resulted from Chantix than any other prescription drug.
The Federal Motor Carrier Safety Administration announced that the use of Chantix may adversely affect a driver's ability to safely operate a commercial motor vehicle and the FAA has already banned the use of Chantix among pilots and air traffic controllers.



The investigation into Chantix's safety was first triggered by the death of a musician named Carter Albrecht, who played keyboards for singer Edie Brickell. While he was taking Chantix, he began banging on the door of his neighbor’s house, yelling and ranting. The neighbor responded by shooting and killing him. While Albrecht's girlfriend has publicly blamed Chantix, he was also drinking around the time of his erratic behavior and it is unclear what role that may have played.



Preliminary assessment of the reports indicates that many patients developed symptoms of depression and suicidal ideation within days or weeks of starting the medication. In addition, not all patients had pre-existing mental illness or were experiencing nicotine withdrawal, both of which could have potentially explained their symptoms had they existed.



While the investigation continues, the FDA is advising health care providers to monitor their patients for any changes in behavior or mood and advises that patients should communicate with their doctors if they experience any changes as well.



One of the latest studies on Chantix suggests that its side effects are no worse with pre-existing history of the patient’s depressive disorder. The findings by Group Health, Free & Clear, and SRI International researchers are reported in a Journal of General Internal Medicine article. The National Cancer Institute (NCI)-funded, randomized COMPASS trial tracked more than 1,100 Group Health patients receiving behavioral treatment and varenicline to quit smoking. It's the first "real-world" examination of varenicline use since the original Food and Drug Administration (FDA) studies that the manufacturer funded.



"People tend to feel more depressed or irritable while quitting smoking, especially if they have had depression before," said lead author Jennifer McClure, PhD, Group Health Center for Health Studies' associate director for research. "And concerns have been raised that varenicline may increase neuropsychiatric symptoms including depressed mood in people with prior depression." Yet she and colleagues found using varenicline didn't worsen mood symptoms such as depression, anxiety, or irritability in people with a likely history of depression compared to others. "Still," she added, "it's prudent for clinicians to follow the FDA's advice of closely monitoring patients on this drug."



For those who consider Chantix for the smoking withdrawal, be aware on the full list of the potential side effects that has been reported (in no particular order):
  1. Diahhroea

  2. Gingivitis (gum disease and inflammation)

  3. Back pain

  4. Arthralgia (joint pain)

  5. Myalgia (muscle pain)

  6. Attention and concentration problems

  7. Sensory difficulties (vision and taste in particular)

  8. Dizziness

  9. Anxiety

  10. Depression

  11. Irritability

  12. Restlessness

  13. Erratic emotions

  14. Polyuria (frequent lavatory breaks)

  15. Menstrual problems and nose bleeds

  16. Difficulty breathing

  17. Hyperhidrosis (excessive sweating)

  18. Hot flushes

  19. Hypertension (high blood pressure)

  20. Suicidal tendancies

















Sources and Additional Information:

Wakefield Self-Report Questionnaire: How do I know if you are depressed?

The boundary between sadness that we all experience from time to time and the illness, depression, is not well defined. Some people may seek treatment for relatively mild feelings of sadness, while others may avoid treatment even though they are severely depressed.






The Wakefield Self-Report Questionnaire permits people who may be depressed to obtain a depression rating score by answering 12 simple questions.



Read these statements carefully, one at a time, and post the score near the question that will be matching with the score opposite the response that best indicates how you feel. It is very important to indicate how you are now, not how you were, or how you would hope to be.



     A.   I feel miserable and sad______
            0) No, not at all
            1) No, not much
            2) Yes, sometimes
3) Yes, definitely



     B.   I find it easy to do the things I used to do______
0) Yes, definitely
1) Yes, sometimes
2) No, not much
3) No, not at all



     C.   I get very frightened or panicky feeling for apparently no reason at all______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely

                
     D.   I have weeping spells, or feel like it______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely

          
     E.   I still enjoy the things I used to______
            0) Yes, definitely
1) Yes, sometimes
2) No, not much
            3) No, not at all



      F.   I am restless and can’t keep still______
            0) No, not at all
            1) No, not much
            2) Yes, sometimes
            3) Yes, definitely




     G.   I get off to sleep easily without sleeping tablets______
            0) Yes, definitely
            1) Yes, sometimes
            2) No, not much
            3) No, not at all

    
     H.   I feel anxious when I go out of the house on my own______
             0) No, not at all
            1) No, not much
            2) Yes, sometimes
            3) Yes, definitely   

               
     
     I.   I have lost interest in things______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely
 

     J.   I get tired for no reason______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely



     K.  I am more irritable than usual______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely



     L.   I wake early and then sleep badly for the rest of the night______
0) No, not at all
1) No, not much
2) Yes, sometimes
3) Yes, definitely



Now summarize your scores per each individual answer and find out your total score.



TOTAL SCORE          _______



In the Wakefield Self-Report Questionnaire, most depressed people score 15 or above, whereas most non-depressed people score between 0 and 14. It is important to realize that a rating scale such as the Wakefield does not diagnose clinical depression. The Wakefield measures the frequency and intensity of symptoms often associated with depression. Some high scores may be attained by individuals with other emotional problems or physical illnesses. Therefore, use the test as a guide, and consider consulting a doctor for an evaluation if your score is 15 or more.



Scores lower than 15 may still warrant consultation with a doctor if your distress or dysfunction is substantial. Repeating the Wakefield approximately two weeks after its first use may be helpful, and if your score is still below 15 but rising, you should strongly consider consulting a doctor.





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