Showing posts with label suicidal thoughts. Show all posts
Showing posts with label suicidal thoughts. Show all posts

Bereavement Leading to Suicide: Statistical Analysis

There is an increased risk of suicidal gestures, completed suicide and death from accidents following the death of a spouse, parent, or a child. The suicide risk for those widowed was first observed over a century ago by Durkheim who found that suicide was higher amongst those widowed compared to those married.


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When   compared   to   the   general   population Mergenhagen and colleagues found the mortality ratio for suicide in young widowers (45–64 years of age) was about four and a half times the rate for married men of similar age. Most studies have found a gender bias with younger men being at the greatest risk of suicide, although Heikkinen and coworkers found evidence of an association between widowhood and women aged 60–69 years.


A 12-year follow-up study in Washington, USA of 6266 white married and 3486 white widowed people aged 60 years and older found death rates from suicide to be 28.7 per 100 000 person years for the married and 40.4 for the widowed. There was also a significant effect from gender with the suicide risk for widowed men estimated to be 3.3 times higher than that for married men, while the risk of suicide for widows and married women was found to be similar.


Several longitudinal studies have found that the risk of suicide is greatest for the period immediately following the loss. MacMahon and Pugh compared 320 widowed people who had committed suicide to a matched sample of widows who had died from non-suicide causes. They found that, although the risk of suicide among the widowed population was generally higher in the first 4 years after the death of the spouse, the risk of suicide in the first year was 2.5 times higher, and in the first, second and third years about 1.5 times higher. The risk at 4 years or more was equal to that of the control group. The age-standardized suicide rate was 3.5 times higher for widowed men than married men. Widows had twice the risk compared to those who were married.


Based on MacMahon and Pugh’s findings, Duberstein and colleagues used the psychologic autopsy method as a way of distinguishing those who committed suicide more than 4 years after the death of their spouse compared to those who committed suicide within 4 years. Although using small numbers (n = 21, > 4 years; n = 14, < 4 years), they found those who committed suicide within 4 years had significantly higher rates of psychiatric treatment, earlier loss or separation from one or both parents and a non-significant (P = 0.07) higher rate of substance abuse. Interestingly, loss of a close interpersonal relationship (including bereavement and separation) is a significant predictor of suicide in alcoholics.


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While the magnitude of the risk varies with the methodology, there's ample evidence that widows/widowers exhibit what actuaries call "excess mortality." Death rates are highest within six months after bereavement and continue high for about three years. Bereavement produces higher mortality among widowers than widows, and among younger ages than older (although the age differences aren't always significant). Socioeconomic status doesn't seem to matter.


Most experts agree there are three main reasons for this phenomenon, although the statistics don't tell you which is most important:
  • Death-related events affecting both spouses at the same time, such as both being in the same accident. Duh, but you can't overlook the obvious.

  • Common risk environment - for example, both spouses live in the same neighborhood subject to the same environmental factors such as pollution. Similarly, both spouses may engage in common health-related behaviors such as smoking or drinking.

  • Direct dependence, where the death of one spouse changes the other spouse's life, also called "broken-heart" syndrome. This is the kind we're mainly interested in, but it can be tough to distinguish from the first two even if you've got the resources for a case-by-case analysis.



Suicide rates are significantly higher for the recently widowed - this was established by pioneering sociologist Emile Durkheim in a classic 1897 monograph. Suicide is most prevalent during the first week after the death of a spouse. There are also higher rates of death due to heart disease and conditions such as cirrhosis.


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The mortality risk is higher for widows/widowers under age 55 when the bereavement was sudden, as from accident. For widows/widowers in the 50-to-65-year range, the highest risk is when the spouse has died of chronic illness. Several studies indicate the risk is lower when the widow/widower has family or other social support and higher when the bereaved is socially isolated.


Why are the bereaved at higher risk? The two broad explanations are grief and stress. Grief can lead to depression and its consequences. Stress can impair the immune system, increasing susceptibility to disease, and trigger dangerous behavioral changes such as higher cigarette and alcohol use. Most data is based on married couples because it's easier to obtain, but there are indications of a similar mortality increase following the death of children, siblings, and parents. Sure, grief is natural and proper, but it's healthier for the survivors to move on.




Sources and Additional Information:
An Atlas of Depression by David S. Baldwin and Jon Birtwistle




Stop-smoking drug Chantix might cause depression

The U.S. Food and Drug Administration (FDA) has issued a notice that it is conducting a safety review of the stop-smoking drug Chantix (varenicline) due to reports of suicidal thoughts and aggressive and erratic behavior in patients who were taking it.








In conducting its review, the FDA will be looking at postmarketing cases submitted by the drug's manufacturer, Pfizer, as well as reports in the press and on internet sites. Chantix (varenicline) is a medication used to quit smoking. Starting from November 2007, when the FDA began investigating reports of depression, agitation, and suicidal behavior among patients taking the medicine as much as 37 Chantix suicides and more than 400 reports of suicidal behavior that may have been linked to Chantix have been received by the end of the year. According to the FDA, a link between Chantix and serious psychiatric complications is becoming progressively probable. Additionally, the drug may worsen preexisting psychiatric illness or cause a recurrence of past issues. By May 2008, Chantix was linked to more than 3,000 reports of serious side effects. By November of the same year, data from the FDA’s Adverse Event Reporting System showed that more reported serious injuries resulted from Chantix than any other prescription drug.
The Federal Motor Carrier Safety Administration announced that the use of Chantix may adversely affect a driver's ability to safely operate a commercial motor vehicle and the FAA has already banned the use of Chantix among pilots and air traffic controllers.



The investigation into Chantix's safety was first triggered by the death of a musician named Carter Albrecht, who played keyboards for singer Edie Brickell. While he was taking Chantix, he began banging on the door of his neighbor’s house, yelling and ranting. The neighbor responded by shooting and killing him. While Albrecht's girlfriend has publicly blamed Chantix, he was also drinking around the time of his erratic behavior and it is unclear what role that may have played.



Preliminary assessment of the reports indicates that many patients developed symptoms of depression and suicidal ideation within days or weeks of starting the medication. In addition, not all patients had pre-existing mental illness or were experiencing nicotine withdrawal, both of which could have potentially explained their symptoms had they existed.



While the investigation continues, the FDA is advising health care providers to monitor their patients for any changes in behavior or mood and advises that patients should communicate with their doctors if they experience any changes as well.



One of the latest studies on Chantix suggests that its side effects are no worse with pre-existing history of the patient’s depressive disorder. The findings by Group Health, Free & Clear, and SRI International researchers are reported in a Journal of General Internal Medicine article. The National Cancer Institute (NCI)-funded, randomized COMPASS trial tracked more than 1,100 Group Health patients receiving behavioral treatment and varenicline to quit smoking. It's the first "real-world" examination of varenicline use since the original Food and Drug Administration (FDA) studies that the manufacturer funded.



"People tend to feel more depressed or irritable while quitting smoking, especially if they have had depression before," said lead author Jennifer McClure, PhD, Group Health Center for Health Studies' associate director for research. "And concerns have been raised that varenicline may increase neuropsychiatric symptoms including depressed mood in people with prior depression." Yet she and colleagues found using varenicline didn't worsen mood symptoms such as depression, anxiety, or irritability in people with a likely history of depression compared to others. "Still," she added, "it's prudent for clinicians to follow the FDA's advice of closely monitoring patients on this drug."



For those who consider Chantix for the smoking withdrawal, be aware on the full list of the potential side effects that has been reported (in no particular order):
  1. Diahhroea

  2. Gingivitis (gum disease and inflammation)

  3. Back pain

  4. Arthralgia (joint pain)

  5. Myalgia (muscle pain)

  6. Attention and concentration problems

  7. Sensory difficulties (vision and taste in particular)

  8. Dizziness

  9. Anxiety

  10. Depression

  11. Irritability

  12. Restlessness

  13. Erratic emotions

  14. Polyuria (frequent lavatory breaks)

  15. Menstrual problems and nose bleeds

  16. Difficulty breathing

  17. Hyperhidrosis (excessive sweating)

  18. Hot flushes

  19. Hypertension (high blood pressure)

  20. Suicidal tendancies

















Sources and Additional Information:
 
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